Optimal tissue
composition with Affinity®

The closest choice to native amniotic membrane

Never dehydrated or frozen, Affinity uses a gentle hypothermic* storage method called AlloFresh™ that preserves the product in its fresh state and retains its native tissue characteristics1,2:

Viable cells—including epithelial cells, fibroblasts, and mesenchymal stem cells (MSCs)1,3,4

Growth factors/cytokinesin vitro studies have shown that these factors are released similarly to unprocessed amniotic membrane1,5

Native extracellular matrix (ECM) structure—with multiple ECM proteins that are important for scaffolding, including collagen types I, III, V, VI, and hyaluronic acid1,4,6

The spongy layer—an abundant source of proteoglycans, glycoproteins, and hyaluronic acid1,7

The epithelium, basement membrane, compact layer, fibroblast layer, and spongy layer in Affinity The epithelium, basement membrane, compact layer, fibroblast layer, and spongy layer in Affinity

*Affinity should be maintained at refrigerated temperature (between 1 °C and 10 °C).

Affinity retains a variety of growth factors and cytokines*1

In vitro studies have shown Affinity retains numerous growth factors and cytokines. These growth factors and cytokines are known to have angiogenic, regenerative, and anti-inflammatory properties.1

Anti-inflammatory cytokines
TGF-α
TIMP-1
TIMP-2
IL-1ra
IL-10
Angiogenic growth factors
aFGF
bFGF
VEGF
EG-VEGF
VEGF-D
PDGF-BB
ANG
TSP-1
ANG-2
PIGF
APL4
Regenerative growth factors
EGF
HGF
GAL
IGF-I
IGF-II
TGF-β1
TGF-β3
IGFBP-1
IGFBP-5
*This is not an exhaustive list.

Total growth factor and cytokine release (in vitro)5

Over 500,000 growth factors/cytokines released in 7 days Over 500,000 growth factors/cytokines released in 7 days

71%
OF AFFINITY GROWTH FACTORS/CYTOKINES ARE RELEASED WITHIN 7 DAYS1

Discover the native structure of Affinity

Learn about AlloFresh, the hypothermic storage method that is used to preserve Affinity, or talk to an Organogenesis Tissue Regeneration Specialist about the only fresh amniotic membrane wound covering.

Contact us

REFERENCES:

  1. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
  2. Data on file. DR-0005. Organogenesis Inc.
  3. Data on file. DR-0006. Organogenesis Inc.
  4. Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
  5. Data on file. DR-0007. Organogenesis Inc.
  6. Mamede AC, et al. Cell Tissue Res. 2012;349(2):447-458.
  7. Ghatak S, et al. Int J Cell Biol. 2015;2015:834893.