composition with Affinity®
The closest choice to native amniotic membrane
Never dehydrated or frozen, Affinity uses a gentle hypothermic* storage method called AlloFresh™ that preserves the product in its fresh state and retains its native tissue characteristics1,2:
Viable cells—including epithelial cells, fibroblasts, and mesenchymal stem cells (MSCs)1,3,4
Growth factors/cytokines—in vitro studies have shown that these factors are released similarly to unprocessed amniotic membrane1,5
Native extracellular matrix (ECM) structure—with multiple ECM proteins that are important for scaffolding, including collagen types I, III, V, VI, and hyaluronic acid1,4,6
The spongy layer—an abundant source of proteoglycans, glycoproteins, and hyaluronic acid1,7
*Affinity should be maintained at refrigerated temperature (between 1 °C and 10 °C).
Affinity retains a variety of growth factors and cytokines*1
In vitro studies have shown Affinity retains numerous growth factors and cytokines. These growth factors and cytokines are known to have angiogenic, regenerative, and anti-inflammatory properties.1
Total growth factor and cytokine release (in vitro)5
- McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
- Data on file. DR-0005. Organogenesis Inc.
- Data on file. DR-0006. Organogenesis Inc.
- Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
- Data on file. DR-0007. Organogenesis Inc.
- Mamede AC, et al. Cell Tissue Res. 2012;349(2):447-458.
- Ghatak S, et al. Int J Cell Biol. 2015;2015:834893.