NEW CASE STUDIES: SEE HOW AFFINITY® HELPED TO SUPPORT HEALING

Optimal tissue
composition with Affinity®

The closest choice to native amniotic membrane

Never dehydrated or frozen, Affinity uses a gentle hypothermic* storage method called AlloFresh™ that preserves the product in its fresh state. In analytical testing, Affinity has been shown to retain its native tissue characteristics1,2:

Viable cells—including epithelial cells and fibroblasts1,3

Growth factors/cytokines—analytical testing has shown that the level of these factors is similar to unprocessed amniotic membrane1,4

Native extracellular matrix (ECM) structure—with multiple ECM proteins that are important for scaffolding, including collagen types I, III, V, VI, and hyaluronic acid1,3,5

The spongy layer—an abundant source of proteoglycans, glycoproteins, and hyaluronic acid1,6

The epithelium, basement membrane, compact layer, fibroblast layer, and spongy layer in Affinity The epithelium, basement membrane, compact layer, fibroblast layer, and spongy layer in Affinity

*Affinity should be maintained at refrigerated temperature (between 1 °C and 10 °C).

Affinity retains a variety of growth factors and cytokines*1

Analytical studies have shown Affinity retains numerous growth factors and cytokines.

Cytokines
TGF-α
TIMP-1
TIMP-2
IL-1Ra
IL-10
Growth factors
aFGF
bFGF
EGF
HGF
VEGF
EG-VEGF
GAL
IGF-I
VEGF-D
PDGF-BB
IGF-II
TGF-β1
ANG
TSP-1
TGF-β3
IGFBP-1
ANG-2
APL4
PIGF
IGFBP-5
*This is not an exhaustive list. The clinical activity of these growth factors and cytokines has not been demonstrated in Affinity.

Discover the native structure of Affinity

Learn about AlloFresh, the hypothermic storage method that is used to preserve Affinity, or talk to an Organogenesis Tissue Regeneration Specialist about the only fresh amniotic membrane wound covering.

Contact us

Affinity is intended to be used as a wound covering and barrier.
Please refer to the Affinity instructions for use for usage and safety information.

REFERENCES:

  1. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
  2. Data on file. DR-0005. Organogenesis Inc.
  3. Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
  4. Data on file. DR-0007. Organogenesis Inc.
  5. Mamede AC, et al. Cell Tissue Res. 2012;349(2):447-458.
  6. Ghatak S, et al. Int J Cell Biol. 2015;2015:834893.