Preserving
natural characteristics

AlloFresh™ retains mesenchymal stem cells (MSCs)

Affinity® undergoes a proprietary preservation method that retains MSCs, as shown in an in vitro study.1 Research has suggested MSCs play an important role in the wound healing process by1-5:

  • Regulating immune response and inflammation
  • Secreting anti-inflammatory cytokines, as well as angiogenic and regenerative growth factors
  • Promoting an organized extracellular matrix (ECM) and secreting matrix proteins

AlloFresh keeps cells viable6,7

  • A gentle preservation method that maintains the product in its fresh state, retaining its native tissue characteristics7-10
  • Avoids the extremes of heat and cold, which can cause protein damage or loss
Placental tissue received

Placental tissue received

×

Donated tissue arrives for processing

Chorion removed

Chorion removed

×

The chorion is separated from the donated amnion tissue

Antibiotic treatment

Antibiotic treatment

×

Amnion tissue is mechanically cleaned and incubated in antibiotic solution for 18-24 hours

Rinsed

Rinsed

×

Amnion is washed to remove antibiotic residue

Affinity sized, added to tray with AlloFresh solution, and sealed

Affinity sized, added to tray with AlloFresh solution, and sealed

×

Bioburden testing is completed on incoming samples, as well as in-process and final packaged product

Refrigerated

Refrigerated

×

Affinity should be stored with refrigeration between 1 °C and 10 °C until ready for use

Affinity details and resources

Explore product details, storage conditions, and our application guide, or talk to an Organogenesis Tissue Regeneration Specialist about the only fresh amniotic membrane wound covering.

Contact us

REFERENCES:

  1. Maxson S, et al. Stem Cells Trans Med. 2012;1(2):142-149.
  2. Otero-Viñas M, et al. Adv Wound Care. 2016;5(4):149-163.
  3. Nuschke A. Organogenesis. 2014;10(1):29-37.
  4. Chen L, et al. PloS One. 2008;3(4):e1886. doi:10.1371/journal.pone.0001886
  5. Hocking AM, et al. Exp Cell Res. 2010;316(14):2213-2219.
  6. Data on file. DR-0008. Organogenesis Inc.
  7. Data on file. DR-0005. Organogenesis Inc.
  8. Data on file. DR-0006. Organogenesis Inc.
  9. Data on file. DR-0007. Organogenesis Inc.
  10. McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.