AlloFresh™ retains mesenchymal stem cells (MSCs)
Affinity® undergoes a proprietary preservation method that retains MSCs, as shown in an in vitro study.1 Research has suggested MSCs play an important role in the wound healing process by1-5:
- Regulating immune response and inflammation
- Secreting anti-inflammatory cytokines, as well as angiogenic and regenerative growth factors
- Promoting an organized extracellular matrix (ECM) and secreting matrix proteins
AlloFresh keeps cells viable6,7
- A gentle preservation method that maintains the product in its fresh state, retaining its native tissue characteristics7-10
- Avoids the extremes of heat and cold, which can cause protein damage or loss
Amnion tissue is mechanically cleaned and incubated in antibiotic solution for 18-24 hours
Affinity sized, added to tray with AlloFresh solution, and sealed
Bioburden testing is completed on incoming samples, as well as in-process and final packaged product
- Maxson S, et al. Stem Cells Trans Med. 2012;1(2):142-149.
- Otero-Viñas M, et al. Adv Wound Care. 2016;5(4):149-163.
- Nuschke A. Organogenesis. 2014;10(1):29-37.
- Chen L, et al. PloS One. 2008;3(4):e1886. doi:10.1371/journal.pone.0001886
- Hocking AM, et al. Exp Cell Res. 2010;316(14):2213-2219.
- Data on file. DR-0008. Organogenesis Inc.
- Data on file. DR-0005. Organogenesis Inc.
- Data on file. DR-0006. Organogenesis Inc.
- Data on file. DR-0007. Organogenesis Inc.
- McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.